This paper introduces divin, a small molecule inhibitor of bacterial cell division that may facilitate mechanistic studies of this BB-94 in vivo process. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm. In contrast to other division inhibitors, divin does not interact with the tubulin homologue FtsZ, affect
chromosome segregation, or activate regulatory mechanisms that inhibit cell division indirectly. Our studies of bacterial cell division using divin as a probe suggest that dividing bacteria proceed through several morphological stages of the cell envelope, and FtsZ is required but not sufficient to compartmentalize the cytoplasmic membrane at the division site. Divin is only moderately toxic to mammalian cells at concentrations that inhibit the growth of clinical pathogens. These characteristics make divin a useful AZD9291 probe for studying bacterial cell division and a starting point for the development of new classes of therapeutic agents.”
“Two new species of carnivorous sponges of the genus Abyssocladia are described. These sponges were collected from Myojin Knoll, Izu-Ogasawara (Izu-Bonin) Arc, in
southern Japan. Detailed morphological observation based on specimen both in situ and preserved revealed functional differentiation of spicule distribution. Abyssocladia natsushimae sp. nov. is distinct within the genus in its mop-like gross morphology, large body size, and soft tissue packed with numerous microspined microstrongyles. Abyssocladia myojinensis sp. nov. is characterized by possession of both typical abyssochelae and palmate abyssochelae. This is the first record of the genus from Japan.”
“Using the large-scale atomic/molecular massively parallel simulator, chemical short-range order of the Cu-Zr binary system over the three good glass-forming compositional ranges has been investigated. Based on a statistical analysis, a simple
route has been developed for broad investigations of the basic polyhedral clusters, optimum glass formers, as well as the composition-structure-property (glass-forming ability) correlation. In addition, topological short-range orders of the basic polyhedral clusters in the three compositional ranges were characterized. Our LXH254 manufacturer findings have implications for understanding the nature, forming ability, and properties of metallic glasses.”
“Zircon LA-ICP-MS U-Pb ages and Hf isotopic as well as whole-rock geochemical data are reported for keratophyes in the Pingshui Group, Zhejiang. The results are used to discuss their petrogenesis and geological significance. The keratophyes were dated at 904 +/- 8 to 906 +/- 10 Ma. These intermediate-felsic rocks are characterized by high LREE contents and depletion of HREE and HFSE (e.g., Nb, Ta, Ti, P), resembling arc-derived rocks. The keratophyes exhibit positive epsilon(Hf)(t) values of 8.6 to 15.