75) (P-trend <0.001), as was in-hospital death (0% for Q1, 2.3% for 02, 5% for Q3 and 12.2% for 04; P-trend = 0.009). Receiver operator characteristic curve analysis showed that an hs-CRP of 16.10 mg/L was a fair discriminator for the early creatinine increase (C statistic 0.78). After adjusting for potential confounding predictors, hs-CRP >16.10 mg/L remained significantly associated with CIN HDAC inhibitor (odds ratio = 6.51; 95% confidence interval, 1.26-33.61).
Conclusion: An hs-CRP >16.10 was a significant and independent predictor of CIN after primary PCI in patients with STEMI.”
“Objective:
Familial adenomatous polyposis (FAP) is characterized by multiple adenomas in the colorectum with a high risk to develop colorectal cancer. It is unclear whether individuals at risk of FA P experience distress due to this potentially life-threatening disease. This nationwide study assessed: (I) the prevalence of psychological distress; and (2) the need for and use of specialized professional psychosocial support.
Methods: In this cross-sectional study, all individuals from families at high risk for FAP registered at the Netherlands Foundation
for the Detection of Hereditary Tumours were invited to complete a questionnaire assessing, among other issues, generalized, cancer-specific and FAP-specific distress.
Results: In total, 525 individuals completed the questionnaire. Approximately 20% of Alvocidib manufacturer the respondents had moderate to severe levels of FAP-specific distress. Levels of generalized distress were comparable to the general Dutch population. Significantly more individuals with a FAP diagnosis had frequent cancer worries than those at risk of FAP or non-carriers (p = 0.02). Distress levels were more strongly associated with
psychosocial variables (e.g. perceived cancer risk), than with sociodemographic or clinical variables. Up to 43% of the variance in distress could be explained by all variables combined. Of those moderately to severely distressed, AP24534 ic50 26% had received specialized professional psychosocial support, while 30% of those did not receive the support they wanted.
Conclusions: A substantial minority of individuals reported moderate to severe distress levels associated with FAP. However, only one-third of those received specialized professional psychosocial support. We recommend the use of a screening questionnaire to identify individuals in need of such support. Copyright (C) 2009 John Wiley & Sons, Ltd.”
“Patient reported outcome measures play an increasingly important role in the outcomes research. The Core Outcome Measures Index (COMI) is a short, multidimensional instrument initially developed for the use by patients with low back pain. This study is an evaluation of a Polish version of COMI adapted for neck pain.
One hundred twenty-three patients complaining of neck pain were enrolled.