To assess the relationship between the CYP46A1 rs754203 polymorphism and AD risk more exactly, relevant literature was recruited by searching the Cochrane Library, PubMed, Medline (Ovid), Embase (Ovid), ISI Web of Science, the Chinese Biomedicine Database (CBM), CNKI, Wan fang, and reference lists of articles. Odds ratio (ORs) and 95% confidence intervals (CIs) were calculated using fixed and random effects models, publication check details bias was tested by funnel plot and Egger’s test, heterogeneity was assessed with 12 statistics.

Sixteen case-control studies were included with a total of 7788 individuals, involving 3960 AD patients and 3828 controls. The combined results showed no significant differences in allele comparison C vs. T (OR=1.04,95% SC79 cell line CI = 0.86-1.26), recessive model CC vs. TC + TT (OR

= 1.24,95% CI = 0.90-1.69) and dominant model CC+TC vs. TT (OR = 1.03, 95% CI = 0.84-1.27). When stratifying for ethnicity, no significant associations were detected in Caucasians or in Asians. Our results suggested that CYP46A1 rs754203 is a minor risk factor for AD. However, more wide samples of highly selected AD patients, based on different onset age and other confirmed genetic factors interactions, are needed to clarify these association and further researches should be carried out to explore the effect of genetic networks, environmental factors, individual biological characteristics and their mutual interactions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.”
“The left paracingulate sulcus (PCS) is longer than the right and the adjacent

cortex is activated by the generation of words. In adult patients with chronic schizophrenia the anatomical asymmetry is reduced. In 35 controls and 38 adolescents with schizophrenia or schizoaffective disorder (mean age = 16 years) we found that semantic verbal fluency correlated with leftward PCS asymmetry in controls but not in patients. At intake, PCS length did not differ between patients and controls, but at follow-up (13 controls, 10 patients, mean age = 18 years) PCS asymmetry (comprising PDK4 both increasing left and decreasing right length) increased significantly, the increase was greater in males than in females, and there was a trend for a diagnosis*sex*side*time interaction such that in controls leftward PCS asymmetry increased, while in patients of both sexes there was convergence toward symmetry. Thus sulcal anatomy develops differentially in the two sexes during adolescence, and the pattern of asymmetric sex-dependent change over time may distinguish patients with psychosis from controls. Greater change in asymmetry during adolescence may explain earlier age of onset in males and greater deficits in verbal fluency. (C) 2010 Elsevier Ireland Ltd. All rights reserved.