These metabolic fingerprints will become an important part of a patient-centered personalized, predictive, preventive, and participatory health care system (Figure 2). Papers of particular interest, published within the period of review, have been highlighted as: • of special interest This work was supported by

the research programme of the Netherlands Metabolomics Centre (NMC), which is a part of The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research. “
“Lynne S. Steinbach Bonnie N. Joe Wendy B. DeMartini and Habib Rahbar Although there are multiple variations in acquisition protocols for breast magnetic CB-839 solubility dmso resonance (MR) imaging, there is agreement that components of high-quality technique include a bilateral acquisition obtained with a dedicated breast coil. Further, key pulse sequences should be included and spatial and temporal resolution should be sufficiently high to assess lesion morphology and kinetics. Artifacts must be recognized and avoided. The American College of Radiology Breast MRI Accreditation Program requirements provide minimum standards to guide facilities in technique. MR imaging at 3 T is increasingly

buy Y-27632 available and offers signal-to-noise ratio advantages over 1.5 T but also some technical challenges Sonya D. Edwards, Jafi A. Lipson, Debra M. Ikeda,

and Janie M. Lee This article summarizes the updates and revisions to the second edition of the BI-RADS MRI lexicon. A new feature in the lexicon is background parenchymal enhancement and its descriptors. Another major focus is on revised terminology for masses and non-mass enhancement. A section on breast implants and associated lexicon terms has also been Digestive enzyme added. Because diagnostic breast imaging increasingly includes multimodality evaluation, the new edition of the lexicon also contains revised recommendations for combined reporting with mammography and ultrasound if these modalities are included as comparison, and clarification on the use of final assessment categories in MR imaging. Mary C. Mahoney and Mary S. Newell Data support greater sensitivity of MR imaging compared with mammography and ultrasound in high-risk populations, in particular BRCA 1 and BRCA 2 carriers. Screening ultrasound improves cancer yield versus mammography alone in high-risk patients and in patients with dense breasts and is less expensive. Drawbacks include low positive predictive value, operator dependence, and significant physician time expenditure.