The antioxidant potential of 70% methanolic extracts from
the flowers and leaves collected over the growing season was evaluated using the 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging and 2,2′-azobis-(2-amidinopropane) dihydrochloride (AAPH)-induced linoleic acid (LA) peroxidation tests in relation to the contents of the isolates 1-6, total phenolics, total proanthocyanidins and total quercetin. The IC50 values were expressed in gram 4-Hydroxytamoxifen molecular weight dry weight per gram of DPPH or LA, respectively, and were in the range of 1.42-2.42 for the DPPH test and 1.78-4.92 for the LA peroxidation, with superior activity found for the flowers and the autumn leaves. Significant linear correlation of these values to the sum of proanthocyanidins and compounds 1-6 (R-2 > 0.87) showed that the listed phenolics are synergists of the tested activity.”
“The solasodine isolated from Solanum trilobatum has been examined for possible anti-inflammatory activity in acute and chronic inflammatory animal models. Solasodine (5, 30 and 75 mg kg (1)) exerted statistically significant and dose-dependent anti-inflammatory activity in carrageenan-induced rat paw oedema, which was similar to that of indomethacin (10 mg kg (1)), a known anti-inflammatory agent. At the dose of 75 mg kg
(1), solasodine inhibited the arachidonic Selleckchem Acalabrutinib acid-elicited rat paw oedema 1 h after arachidonic acid challenge. Topical application of solasodine significantly inhibited the ear inflammation induced by multiple applications of tetradecanoyl-phorbol 13-acetate. It also suppressed the volume of exudates, total leucocytes and amount of neutrophil migration into the rat pleural cavity. Administration of solasodine at a dose of 75 mg kg (1) significantly inhibited the adjuvant-induced rat paw oedema.
These results suggest that solasodine exerts anti-inflammatory activity, at least partly through the inhibition of cyclooxygenase and 5-lipoxygenase pathways.”
“The aim of this study was to investigate the antimycobacterial activity of the GSK2879552 nmr major daucane constituent, ferutinin (jaeschkeandiol p-hydroxybenzoate, 1), four of its natural analogues, its hydrolysis products, as well as methyl p-hydroxybenzoate (methylparaben) against Mycobacterium smegmatis, a rapidly growing surrogate of Mycobacterium tuberculosis. The agar dilution assay was utilised for an antimycobacterial evaluation of single compounds. A modified agar dilution assay, the checkerboard method, was utilised for evaluating the potentiating effect of 1 on different antitubercular drugs, namely isoniazid, ethionamide, rifampin and streptomycin. In the agar dilution assay, 1 exhibited higher potency (minimum inhibitory concentration [MIC] 10 mu g mL(-1)) than streptomycin and rifampin (MIC 20 mu g mL(-1) for each).