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“1 Introduction Blood pressure (BP) fluctuates daily in a circadian pattern, i.e., it
is elevated from evening to morning, and the frequency of myocardial infarction or stroke is also increased during the same period [1, 2]. Morning BP correlates with cardiovascular events, and therefore morning hypertension during the high-risk hours is very important [3–5]. Organ damage is related more to morning hypertension than to hypertension defined on the basis of Baricitinib measurement of BP at the clinic (clinic BP) [6]. Morning hypertension has been reported to be associated with an increased risk of future stroke [4, 7]. Although there is no consensus definition of morning hypertension, one practical definition is BP of 135/85 mmHg or higher measured at home in the morning (morning home BP) [8]. In the Ambulatory Blood Pressure Monitoring (ABPM) Study [7], subjects were classified using the following thresholds: (i) an average of morning and evening systolic BP [ME average] of 135 mmHg; and (ii) a www.selleckchem.com/products/p5091-p005091.html difference between morning and evening systolic BP (ME difference) of 20 mmHg; the relative risk of stroke was compared in the resulting four groups of subjects with normal BP, normal BP with a morning BP surge pattern, sustained hypertension, and morning-predominant hypertension. The risks of stroke were 2.1 and 6.