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B, et al.: Immunohistochemistry to detect hereditary nonpolyposis colorectal cancer in young patients: the 7-year Auckland experience. Dis Colon Rectum 2011,54(5):552–558.PubMedCrossRef 41. Ahnen DJ: The American college of gastroenterology Emily couric lecture — the adenoma – carcinoma sequence revisited: has the Era of genetic tailoring finally arrived? Am J Gastroenterol 2011, 106:190–198.PubMedCrossRef 42. Berndt SI, Platz EA, Fallin MD, et al.: Mismatch repair polymorphisms and the risk of colorectal

cancer. Int J Cancer 2007, 120:1548–1554.PubMedCrossRef 43. Bussolati G, Leonardo E: Technical NU7026 mw pitfalls potentially affecting diagnoses in immunohistochemistry. J Clin Pathol 2008, 61:1184–1192.PubMedCrossRef 44. Hassen S, Boman BM, Ali N, et al.: Detection of DNA mismatch repair proteins in fresh human blood lymphocytes – towards a novel method for hereditary non polyposis colorectal cancer (lynch syndrome) screening. J Exp Clin Cancer Res 2011, 30:100.PubMedCrossRef Competing interests The authors declare that they have Tenoxicam no competing interests. Authors’ contributions VS conceived of the study, participated in its design and coordination and performed clinical and endoscopic examination. LSM collected data, performed clinical and endoscopic examination and drafted the manuscript. AM carried out the mutational analysis, MD and BC carried out immunohistochemistry and Microsatellite instability analysis, IS performed statistical analysis and MA provided a critical revision of the manuscript. All authors read and approved the final manuscript.”
“Background Pancreatic carcinoma is the tenth most common malignant tumor, but is the fourth most common cause of cancer-related deaths worldwide [1]. Less than 20% of pancreatic carcinoma patients are suitable for surgical resection, the majority of cases of pancreatic carcinoma are diagnosed at the locally advanced or metastatic stage.

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