One week later, the rats were perfused and the brainstems from these animals were analyzed for the presence of neurons that co-contained CTb and tryptophan hydroxylase (synthetic enzyme for 5-HT) immunoreactivity. Co-labeled neurons were found mainly in the area postrema and to a lesser degree, in the dorsal
raphe nucleus. We propose that the 5-HT inputs to the pre-LC and PBel-inner may selleck modulate the salt appetite-related functions that influence the reward system. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Endovascular repair of aneurysms involving the visceral segment of the abdominal aorta still remains a challenge. We report a patient with a large saccular aneurysm involving the visceral segment of the abdominal aorta that was ultimately excluded by endovascular deployment of an Amplatzer atrial septal occluder device (AGA Medical/St. Jude Medical, St Paul, Minn). (J Vase Surg 2011;53:1097-9.)”
“In the present study we investigated whether individuals would take advantage of an extrinsic and incidental reappraisal strategy by giving them precedent descriptions to attenuate the emotional impact of unpleasant pictures. In fact, precedent descriptions have successfully promoted this website down-regulation of electrocortical activity and physiological responses to unpleasant pictures. However, the neuronal substrate
underlying this effect remains unclear. Particularly, we investigated whether amygdala and insula responses, brain regions consistently implicated in emotional processing, would be modulated by this strategy. To achieve this, highly unpleasant pictures were shown in two contexts in which a prior description presented them as
taken from movie scenes (fictitious) or real scenes. Results showed that the fictitious condition was characterized by down-regulation of amygdala and insula responses. Thus, the present study provides new evidence on reappraisal strategies to down-regulate emotional reactions and suggest that amygdala and insula responses to emotional stimuli are adaptive and highly flexible. (C) 2011 buy Ispinesib IBRO. Published by Elsevier Ltd. All rights reserved.”
“Viral vector-mediated gene transfer has become increasingly valuable for primate brain research, in particular for application of genetic methods (e.g. optogenetics) to study neuronal circuit functions. Neuronal cell tropisms and infection patterns are viable options for obtaining viral vector-mediated transgene delivery that is selective for particular neuronal pathways. For example, several types of viral vectors can infect axon terminals (retrograde infections), which enables targeted transgene delivery to neurons that directly project to a particular viral injection region.