https://www.selleckchem.com/products/sbi-0206965.html Management of patients presenting with abscess or phlegmon is conservative, with antibiotics and drainage initially. Traditionally this has been followed by interval appendectomy. However, recently the need for interval appendectomy has been questioned. Controversy primarily surrounds the issues of recurrence and potential for malignancy. In a large review the recurrence rate was 7.4% and the risk of malignancy 1.2%[57]. This is in accord with similar studies that conclude that in asymptomatic patients, interval appendectomy has no advantages over a thorough work up for inflammatory appendiceal masses[58, 59]. Gastroduodenal

perforation After bleeding, perforation is the second most common complication requiring emergent operative intervention in peptic ulcer disease[60, 61]. Helicobacter pylori infection is the Ferrostatin-1 datasheet most common cause of gastric and duodenal ulcers. Since the development of treatments for H. pylori, its prevalence in the United States has decreased. However, prevalence of gastric and duodenal ulcers has remained the same[62]. Previously, ulcer perforation was treated by excision

and vagotomy. However, with antimicrobial eradication and anti-secretory pharmaceuticals, https://www.selleckchem.com/products/AG-014699.html H. pylori positive ulcer recurrence has been significantly reduced[63]. As a result, the current standard of care is simple ulcer excision

and primary repair of the bowel defect, or omental patch and subsequent H. pylori eradication, with little or no role for anti-secretory ulcer surgery[61, 64]. Both open and laparoscopic approaches are reasonable options for treatment of perforated peptic ulcers. Laparoscopic surgery is associated with significantly less pain, but downfalls include longer operative times, and potentially inadequate repair of large perforations. Comparisons of sutured versus non-sutured repair with fibrin glue plug reveal that both are safe[65]. Conservative management has also been proposed as a safe option for management of contained or sealed gastroduodenal perforations. One randomized study showed similar morbidity and mortality over for operative and conservative approaches; however, conservative treatment was associated with longer hospital stays and increased failure in patients over 70 years old[66]. Similarly, another author suggests that patients less than 40 years old and not on NSAIDS are the most likely to be infected with H. pylori and therefore, the most likely to benefit from non-operative therapy[67]. Alternatively, one group suggests that non-operative therapy can be guided by documented self-sealing on gastroduodenogram[68]. Diverticulitis Diverticular disease has increased since the turn of the 20th century[69].