Japan is the only country in Asia that reported the incidence rate on morphometric selleckchem vertebral fractures based on a radiographic survey in a community-based population. Also, the Japanese data used for comparison came from the early 1990s, and there has been some evidence that hip fracture rates are increasing in Asians [20]. The impact on the change in epidemiology of fracture in Asians has not been evaluated. Another drawback of the present study is that only the incidences of clinical vertebral fractures were reported due to the lack of a common definition of morphometric vertebral fractures

in other publications. Furthermore, the sample size and the number of fractures recorded in the men’s cohort were small, and this study may have underestimated the fracture rates in the general male population. In conclusion, this study demonstrated that while the hip fracture incidence in Asians is lower than in LY411575 Caucasians, the incidence of clinical vertebral fractures was at least as high in Asians as in Caucasians. Acknowledgements This study was funded by the Bone Health Fund of

the Hong Kong University Foundation and the Osteoporosis Research Fund of the University of Hong Kong. SMCR is partly supported Epacadostat in vitro by the KC Wong Education Foundation. Conflicts of interest None. Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References 1. Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359:1761–1767PubMedCrossRef 2. Delmas PD, Genant HK, Crans GG et al (2003) Severity Dipeptidyl peptidase of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 33:522–532PubMedCrossRef 3. Ettinger B, Black DM, Nevitt MC et al (1992) Contribution of vertebral deformities to chronic back pain and disability. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res 7:449–456PubMedCrossRef

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