(J Am Vet Med Assoc 2012;240:199-204)”
“Purpose of reviewTo review the association of pregnancy with the risk of subsequent development of rheumatic autoimmune diseases in women, including rheumatoid arthritis (RA), systemic lupus erythematosus, and scleroderma.Recent findingsThere is a small but growing literature
related to the risk of autoimmune rheumatic disease in association with pregnancy history. However, AZD1208 chemical structure results conflict both in terms of the direction and magnitude of risk of disease in relationship to prior pregnancy history. Although anecdotal evidence tends to favor the premise that pregnancy is protective against certain diseases, such as RA, the heterogeneity of results precludes
the ability to confirm an association in either direction. There is indication that time elapsed since pregnancy may influence risk, with the postpartum year being of particular relevance.SummaryTo date, a clear pattern has not emerged regarding pregnancy and the future risk of autoimmune rheumatic diseases. This topic requires greater study, and given the strong female preponderance of these diseases, future research efforts should seek to resolve this important issue.”
“(18)F-Labelled fluoroazomycin arabinoside ([(18)F]FAZA) is a 2-nitroimidazole (azomycin) based PET tracer used extensively in cancer clinics to diagnose tumour hypoxia. The hypoxia-specific uptake and rapid blood Epigenetic inhibitor libraries clearance kinetics of FAZA contribute to good tumor-to-background ratios (T/B ratios) and high image contrast. However, FAZA, an alpha-configuration nucleoside, is not transported by cellular nucleoside transporters. It enters cells only via diffusion, therefore not achieving the high uptake and T/B ratios characteristic
of actively transported radiopharmaceuticals. The present work describes the synthesis, physicochemical properties and preliminary assessment of the radiosensitization properties of two novel azomycin nucleosides, 1-beta-D-(2-deoxy-2-fluoroarabinofuranosyl)-2-nitroimidazole Roscovitine mouse (beta-2-FAZA) and 1-beta-D-(3-deoxy- 3-fluorolyxofuranosyl)-2-nitroimidazole (beta-3-FAZL) (fluorination yields 60% and 55%, respectively). The tosylated precursors required to synthesize the corresponding F- 18 labeled radiopharmaceuticals are also reported. The partition coefficients (P) for beta-2-FAZA (1.0) and beta-3-FAZL (0.95) were marginally lower than reported for FAZA (1.1). The radiosensitization properties of both these compounds are similar to that of FAZA, with sensitizer enhancement ratios (SER) of similar to 1.8 for HCT-116 cells.”
“In previous work using thin superconducting films as photon detectors it has been assumed implicitly that the quasiparticle yield in proximized superconducting bilayers should be the same as for a pure superconducting layer with the same energy gap.