In conclusion, EHEC O111 can cause severe illness in children and adults, and the prognosis becomes poorer as the severity of complications increases. Close monitoring including platelet counts and LDH are useful. Once these clinical

parameters change, intensive treatment should be provided to prevent the development of severe complications.”
“Objectives. – To analyse the prevalence of abnormal papsmears in a primary care center and the screening practices. Materials and methods. – Single-center retrospective study on 1,430 FCU performed in 1,251 patients between January 2009 and RG-7112 in vivo December 2011 with analysis of demographic, clinical and epidemiological chararacteristics of the women, and the monitoring www.selleckchem.com/products/p5091-p005091.html of the patients with pathological papsmears. Results. – The study population was predominantly young (under 25), unmarried, nulliparous, and using contraception. Among the 1,244 FCU, nearly 90% of them were interpretable with the junction area interested. Nine percent were pathological with mainly ASC-US and L-SIL (3.5% and 4.5%) with no difference between more and less than 25 years. Two factors were significantly associated with the presence of pathological papsmear: first intercourse before age 14 and smoking more than 10 cigarettes per day. Monitoring of patients with a pathological papsmear showed that 33% of patients had not an appropriate follow-up especially younger patients. Discussion. – To perform papsmear

before 25 years because the patient has associated high risk HPV co-factors does not appear justified by the severity or frequency of cytological lesions, especially as it increases the financial cost and is responsible of potential deleterious actions such as conizations probably excessive among the youngest patients. Personalized monitoring of these patients with a pathological papsmear is required. The French practice recommendations on cervical cancer screening Selleck GSI-IX (first screening at age 25, 26 years cytological control then every 3 years up to 65 years in patients who have or have

had sex) deserve to be applied in young and disadvantaged patients. (C) 2013 Elsevier Masson SAS. All rights reserved.”
“Endocrine tumors were considered relatively infrequent neoplasms. However, during the last decades, their frequency gradually increased. The use of imaging techniques, guided FNA biopsy, an endoscope camera in the investigation of endocrine lesions, permits early diagnosis. At the histological level, new applications such as non-biotin containing immunohistochemical detection systems, tyramide amplification method, in situ hybridization, FISH, CGH, and other molecular techniques have provided better knowledge on the protein and molecular background. The investigation of somatostatin and dopamine receptors assists targeted therapy of endocrine tumors. Novel treatment modalities have emerged for the management of pituitary and gastroenteropancreatic tumors respectively.