In addition, we have determined a positive correlation between the expression of GmGAD genes and GABA accumulation during the germination process. Furthermore, the induction of GmGAD1, 4, and 5 transcripts following infection of hypocotyls with Phytophthora sojae suggests that GABA may

play a role in the resistance mechanism. Taken together, our comparative genomic analysis of GAD genes and encoded proteins in soybean is the first step toward the functional dissection of this family, and we present information that will assist future studies on GABA metabolism and signaling research. (C) 2013 Elsevier B.V. All rights reserved.”
“The aim of this study was to develop and validate a linguistically and culturally appropriate version of the Edinburgh Postnatal Depression Scale (EPDS) for use with women attending antenatal care in Romania. We translated BIX 01294 clinical trial SBE-β-CD in vivo and tested a Romanian version of the EPDS (EPDS-R) in four hospitals in three Romanian cities: Cluj-Napoca, Satu Mare, and Sighetu-Marmatiei. The study population included third-trimester women attending antenatal clinics (n=418); 364 subjects were included in the analytic sample. We used the Center for Epidemiologic Studies Depression Scale (CES-D) as a “”gold standard”". We assessed reliability, validity, and conducted sensitivity analysis to establish an EPDS-R cutpoint. We found that reliability was

robust (alpha=0.89) and there was a significant linear relationship between EPDS-R and CES-D scores (r=0.77; p < 0.001). We established an EPDS-R cutpoint of > 12 to balance sensitivity and specificity. Principal component analysis revealed a two-factor solution. We detected antenatal depressive symptoms prevalence Proteasome inhibitor rates of 32% (CES-D) and 38% (EPDS-R). This is the first study to report exclusively on antenatal depression and the use of the EPDS in Central and Eastern Europe. The EPDS-R is easy to administer, reliable, and valid for screening depression

among antenatal women in Romania.”
“Herpesvirus infections cause morbidity in lung transplant recipients. The study was conducted to investigate the incidence and impact of herpes simplex virus (HSV) and cytomegalovirus (CMV) detection in the respiratory tract (RT) of lung and heart-lung transplant recipients (LTR) during the postoperative phase. In a prospective cohort study, 91 LTR having at least 1 nasopharyngeal swab (NPS) sent for virus diagnostics were monitored for CMV and HSV detection in NPS during their post-transplant hospital stay on cardiothoracic surgery wards (median 4 weeks) by direct immunofluorescence testing for HSV, virus culture, and CMV and HSV polymerase chain reaction (PCR). Bronchoalveolar lavages (BALs) were analyzed with the same protocol except that HSV PCR was only performed on request. Risk factor analysis for the outcome ’90-day mortality’ was performed. Fifteen LTR had virus detection in NPS (16.5%): 9 had CMV, 5 had HSV, and 1 had both CMV and HSV. Four of 84 LTR had CMV detection in BAL (4.8%).