Five patients (22%) required 1 reintervention. Surgical repair significantly GDC-0068 solubility dmso reduced the total pulmonary vein stenosis score (5.6 +/- 2.10 before repair, 2.6 +/- 2.72 after repair, P = .0057). The preoperative pulmonary vein stenosis score was the only independent predictor of mortality (hazard ratio, 1.732; P < .01). A preoperative pulmonary vein stenosis score of greater than 4 was a poor prognostic indicator (area under the curve, 0.83).
Conclusions: Mortality and restenosis rates remained high despite the adoption of a sutureless technique. A preoperative pulmonary vein stenosis score of greater than 4 was a strong predictor of poor prognosis. (J Thorac Cardiovasc Surg 2011; 142: 344-50)”
“Background.
The association between personality traits and the first lifetime onset of clinically significant depression has not been studied in older adults.
Method. Experienced psychiatrists conducted interviews and chart reviews
at baseline and throughout the 15-year follow-up period. Survival analyses were conducted on the check details presence/ absence of a DSM-III-R mood disorder at follow-up.
Results. There were 59 cases of first lifetime episodes of depression. Analyses showed that Neuroticism [hazard ratio (HR) per one point increase in the Maudsley Personality Inventory (MPI) = 1.05, 95 % confidence interval (CI) 1.02-1.08] but not Extroversion (HR 1.02, 95 % CI 0.97-1.06) amplified risk for mood disorder.
Conclusions. This prospective study on a randomly over sampled birth cohort of older adults showed that Neuroticism confers risk for a first lifetime episode of clinically significant depression. Findings have implications for understanding the etiology of late-life depression (LLD) and could also aid in the identification and treatment of people at risk.”
“Objectives:
Durability of bioprosthetic valves in the pulmonary position is not well defined. We examined the durability of bioprosthetic valves in the pulmonary position and risk factors associated with bioprosthetic pulmonary valve failure.
Methods: Between 1993 and 2004, 181 patients underwent pulmonary valve replacement using bioprostheses. Patients who underwent valved conduit or homograft implantation were excluded. Mean age was 14.2 +/- 9.8 years and median valve size was 23 mm (range, 19-27 mm). Types of bioprosthesis used were Hancock II (n = 83), Perimount (n = 53), Freestyle (n = 23), Carpentier-Edwards porcine valve (n = 18), and others (n = 4).
Results: There were 3 early and 7 late deaths. Follow-up completeness was 88.6% and mean follow-up duration was 7.3 +/- 2.9 years. Forty-three patients underwent redo pulmonary valve replacement. Overall freedom from redo pulmonary valve replacement at 5 and 10 years was 93.9% +/- 1.9% and 51.7% +/- 8.6%, respectively. Overall freedom from both valve failure and valve dysfunction at 5 and 10 years was 92.2% +/- 2.1% and 20.2% +/- 6.7%, respectively.