All of these parameters were compared between the Sano and MBT shunt cohorts. A total of 14 specimens (7 Sano and 7 MBT shunt) were studied. Median age at transplant/death of Sano and MBT shunt cohorts was 11 (range 2-41) and 8 months (range 2-200), respectively. All Sano specimens had a scar at ventriculotomy site, and the mean
scar area was 6.2 +/- A 3.3 cm(2). Compared with remote RV free wall, myocardium bordering the scar showed increased fibrosis (34 +/- A 16 % vs. 28 +/- A 14 %, p = 0.04) and thinning (0.8 +/- A 0.9 vs. 5.3 +/- A 0.8 mm; p < 0.001), which did not regress with time. The Sano ventriculotomy site showed significantly decreased velocity, strain, and strain rate compared with the corresponding contralateral segment. No focal scarring or regional hypokinesia was seen in the MBT shunt check details cohort. This is the first study to demonstrate Akt inhibitor histopathological features of ventriculotomy-associated RV myocardial scarring and myocardial thinning. The scarred ventriculotomy site showed decreased segmental myocardial deformation after Norwood with Sano shunt.”
“SETTING: Eleven referring hospitals in South Korea.
OBJECTIVE: To classify the phenotypes in elderly subjects with obstructive lung disease (OLD).
METHODS: We analysed 191 subjects aged >= 60 years with chronic respiratory symptoms and either obstructive spirometry or bronchial hyperresponsiveness.
Factor analysis was performed using commonly measured variables and revealed four significant variables: 1) the ratio of inspiratory capacity to total lung capacity, 2) the total score on the St George’s Respiratory Questionnaire, 3) the volume fraction of the lung less than 950 Hounsfield Unit at full inspiration on volumetric computed tomography and 4) post-bronchodilator forced expiratory volume in 1 second (FEV(1)) changes. We performed a cluster analysis on these four variables.
RESULTS:
The mean age was 68.5 (+/- 5.2 SD) years and the mean post-bronchodilator FEV(1) was 52.4% (+/- 16.5) predicted. Three clusters with the following phenotypes were identified: Cluster 1 included subjects with moderate to severe airflow obstruction and bronchodilator reversibility; Cluster 2 subjects had moderate airflow DAPT order obstruction without bronchodilator reversibility, and Cluster 3 subjects had severe airflow obstruction without bronchodilator reversibility.
CONCLUSIONS: We identified three phenotypes in elderly subjects with OLD. Follow-up studies are needed to explore the clinical significance of each phenotype.”
“The objective of this study was to measure intima-media thickness (IMT) of the abdominal aortic (aIMT) and common carotid (cIMT) arteries in normal term newborns. We measured aIMT and cIMT using high-resolution ultrasonography in 100 normal term newborns during the first 4 days of life. Mean abdominal aIMT and cIMT values of term newborns were 0.51 +/- A 0.041 mm (n = 100) and 0.37 +/- A 0.054 mm (n = 100), respectively.