All databases were searched from inception to November 2012. Update searches were NVP-BKM120 mouse run in November 2013. No date, study design, or language restrictions were imposed. The reference lists of all included articles and identified review articles were checked for additional relevant studies. Forward citation searching for each included article was conducted using ISI Web of Knowledge. We were interested in the effectiveness of interventions (eg, staff training, regular medication

review) designed to reduce inappropriate prescription of antipsychotic medications to individuals with dementia in community residential care settings. Interventions had to be aimed at professionals (eg, general practitioners, community psychiatrists, pharmacists) responsible for prescription of these medications in these settings. We also were interested in reports of the views and experiences of prescribers using the included interventions. All quantitative studies reporting comparative data were included. Qualitative studies using recognized methods of qualitative data collection (eg, focus groups, interviews, and observation) and analysis (grounded theory, narrative analysis, thematic analysis, discourse analysis) were sought. The search results were uploaded to reference management software (Endnote X5, V5; Thomson Reuters, Philadelphia,

http://www.selleckchem.com/products/VX-765.html PA). Titles and abstracts were screened for relevance independently by 2 reviewers (J.T.C., M.R., or R.A.), with any disagreements being resolved by discussion and involvement of a third reviewer (J.T.C., M.R., or R.A.) where necessary. The full text of potentially relevant articles was retrieved

and screened in the same way using the prespecified inclusion and exclusion criteria. All duplicate articles were double-checked and excluded. For each study, details of the intervention, the characteristics of those receiving it, the characteristics of the patient population involved, the setting, the study methods, and outcomes relating to medication Isotretinoin use were recorded. Data were extracted by one reviewer (J.T.C. or M.R.) into a data extraction form based on the Cochrane Effective Practice and Organisation of Care Review Group Data Collection Checklist,16 which was piloted on several studies and refined. The Cochrane Effective Practice and Organisation of Care Review Group Data Collection Checklist includes a taxonomy of intervention components, which was completed for each trial as part of this process. Data were collected from published articles only; manuals were not requested from trial authors. All data extraction was checked by a second reviewer (J.T.C. or M.R.) with discrepancies resolved by discussion and involvement of a third reviewer (R.A.) where necessary.