Accordingly, Peptide 17 price international guidelines recently published by the European Crohn’s and Colitis Organization (ECCO), recommend screening for latent infections, and immunization of all IBD patients, and in particular those who receive or are scheduled to start an immunosuppressive drug. However, clinical experience has revealed that it is difficult to implement these recommendations in an everyday clinical setting. Aim: To investigate if a program of systematic

information about immunization status and vaccination recommendations will increase adherence to vaccination and screening guidelines in patients with IBD on immunosuppressive therapy. Methods: Methods: The study consists of two parts: 1) An observational retrospective part including patients with IBD in in anti-TNF-α (tumor necrosis factor) therapy, and other immunosuppressive therapy from the IBD Clinic at Herlev Hospital. Patients will be interviewed regarding immunization selleck and adherence to vaccination guidelines. 2) An interventional prospective study in which healthcare professionals will receive information about international and local guidelines. Likewise patients will receive systematic information about importance of vaccination and screening. Patients

attending the IBD clinic in the study period will be included. Patients will be interviewed after one year using the same questions as in the retrospective study. Results: Endpoints: The proportions of patients in each of the two substudies who check details are: 1) fully adherent to the screening and vaccination program; 2) partially adherent; 3) completely non-adherent.

Furthermore, the physicians’, nurses’ and patients’ reasons for not following the recommendations for screening and vaccination. Conclusion: In conclusion, the study will show whether systematic information improves adherence to recommended screening and vaccination guidelines, and thereby aid to improve safety. Key Word(s): 1. IBD; 2. Immunosuppressiva; 3. Vaccination; 4. Guidelines; Presenting Author: XIAOFEI ZHANG Additional Authors: WENYU JIANG, WENJIE LI, XIUQIN CHENG, HONGJIE ZHANG Corresponding Author: HONGJIE ZHANG Affiliations: First Affiliated Hospital of Nanjing Medical University Objective: Cytokine signaling (SOCS)-3 plays an important role in autoimmune disorders. High levels of SOCS3 were observed in Crohn’s disease(CD). MicroRNAs(miRNAs) can regulate gene expression during immune responses. The aim of our study was to investigate the contribution of SOCS3 expression-associated miRNA to the regulation of chemokines production in colonic epithelial cells(CEC) in active CD. Methods: Targetscan Human 6.2 was used to screen miRNAs which may be target the 3′ untranslated region(3′ UTR) of SOCS3, and quantitative PCR was used to detect these miRNAs levels in active CD and healthy subjects. The luciferase reporter assay was performed to confirm the target gene.