A regression analysis was performed to assess differences in mean relative telomere length between migraine patients and healthy controls. Results.— The

RNA Synthesis inhibitor leukocyte telomeres of a cohort of 142 Caucasian female migraine subjects aged 18-77 years and 143 matched 17-77-year-old healthy control Caucasian women were examined. A significantly shorter relative telomere length was observed in the migraine group compared with the control group after adjusting for age and body mass index (P = .001). In addition, age of onset was observed to associate with the loss of relative telomere length, especially at early age of onset (<17 years old). No association was observed between relative telomere length and the severity and frequency of migraine attacks and the duration of migraine. Conclusion.— Telomeres are shorter in migraine patients and there is more variation in telomere length in migraine patients. "
“Complementary and Alternative Medicine (CAM) approaches are widely used small molecule library screening among individuals suffering from headache. The medical literature has focused on the evidence base for such use and has largely ignored the fact

that these approaches are in wide use despite that evidence base. This article focuses on the uses of CAM by patients and suggests strategies for understanding and addressing this use without referring back to the evidence MCE公司 base. The rationale for this discussion pivots on the observation that patients are already using

these approaches, and for many there are anecdotal and historical bases for use which patients find persuasive in the absence of scientific evidence. Until such time as the body of scientific literature adequately addresses non-conventional approaches, physicians must acknowledge and understand, as best as possible, CAM approaches which are in common use by patients. This is illustrated with a case study and examples from practice. This article does not review the evidence base for various CAM practices as this has been done well elsewhere. There is a French proverb, dating from the late 13th century that proclaims: “It is the poor craftsman who blames his tools.” But there is a belief in headache medicine (and elsewhere) that, if only we had the proper tools, we could meet all our patients’ expectations. Similarly, there is another belief, widely held, perhaps not consciously, by many of our patients that the tools to manage their headaches exist, but their doctors, as “Western,” evidence-based practitioners, are unaware, inappropriately skeptical, or simply arrogantly biased when it comes to implementing non-Western approaches. And so they seek these alternatives out, often clandestinely.