Exercise training is indicated for underweight patients with COPD.”
“Objective: The purpose of this study was to determine the nature and extent of depressive symptoms among patients with epilepsy. Methods: Ninety patients were investigated over a three-month period: 42 were suffering from generalized TPX-0005 cell line epilepsy, 29 from focal epilepsy and 19 from

undetermined epilepsy. ALL completed the Zung self-rating scale for assessment of the depressive symptoms. Results: Sixty-seven patients felt stigmatized because of epilepsy (67%): 73.6% in the undetermined epilepsy group, 55.1% in the focal epilepsy group and 88% in the generalized epilepsy group. Moreover, among the 90 epileptic patients studied, symptoms of irritability, indecisiveness, personal devaluation and emptiness showed a constant increasing trend for their presence from the undetermined epilepsy group through the generalized epilepsy group to the focal epilepsy group. Conclusions: These findings indicate that although the focal epilepsy patients felt Less stigmatized, they did not

differ greatly in terms of depressive symptoms, in relation to the undetermined epilepsy and generalized epilepsy patients.”
“Purpose: To develop sustained release matrix tablets of diltiazem hydrochloride (DTZ) using modified karaya gum (MK).

Methods: MK was prepared by cross-linking karaya gum with tri-sodium tri-metaphosphate (STMP) which was used as a cross linker. Matrix tablets of DTZ were prepared this website using varying ratios of unmodified karaya gum (K) and MK by direct compression. The matrix tablets were evaluated for pharmacotechnical properties and in vitro release. The optimized formulation was compared with a reference, Dilzem (R) SR. MK and the formulations were also characterized by scanning electron microscopy (SEM), Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC).

Results: Tablets formulated with MK showed higher mean dissolution time (MDT)

and lower dissolution efficiency than those prepared with karaya gum. Drug release was by water uptake, diffusion and erosion mechanisms. Drug release for tablets prepared with pure K was 99.9% at the end of 10 h while that tablet made with MK was 68.2% at the end of 12 h. MK sufficiently Bcl-2 inhibitor controlled the drug release unlike K which exhibited rapid drug release efficiency. SEM images of the tablets before and after dissolution showed some morphological changes on the tablet surface while FTIR and DSC thermogram studies confirmed that there was no chemical interaction between the drug and the polymers in MK formulation. Formulation F6 compared well with Dilzem (R) SR (reference) (p < 0.05) in terms of release characteristics.

Conclusion: The results of the study demonstrate that modified karaya gum is a potential matrix material for formulating suitable sustained-release matrix tablets of diltiazem.