5 mg/day)). Therefore, we analyzed whether Micombi (R) BP (high-dose telmisartan (80 mg/day)/HCTZ (12.5 mg/day)) could provide
better results with regard to efficacy and safety for patients with uncontrolled hypertension.
Methods: In total, 44 hypertensive patients (22 males, age 71 +/- 14 years) who showed uncontrolled BP despite the use of high-dose ARBs or Preminent (R) were enrolled in this study. We used a changeover design in which the CYT387 inhibitor patients were switched from high-dose ARBs or Preminent (R) to Micombi (R) BP. We analyzed BP, heart rate (HR), and biochemical parameters before and after treatment for 3 months.
Results: Systolic BP and diastolic BP significantly decreased (125 +/- 15/69 +/- 11 mmHg) and 85% of the
patients achieved their target BP at 3 months after changeover. Patients who switched from ARBs and those who switched from Preminent (R) showed similar BP-lowering effects. In addition, the reductions in BP after 3 months in patients with or without chronic kidney disease and in those with or without metabolic syndrome (MetS) were also similar. There were no significant changes in HR during the study period. Although blood levels of potassium, hemoglobin A1c and uric acid (UA) significantly increased after 3 months for all of the patients, none of the patients showed serious adverse buy Dihydrotestosterone effects.
Conclusion: High-dose telmisartan/HCTZ therapy was associated with a significant reduction in BP and helped patients achieve their target BP.”
“Pregnancy and lactation are periods of significant influence on bone metabolism that has not been
investigated in equines. To examine the influence of late pregnancy and lactation on bone metabolism in mares, the changes in the blood serum/plasma total calcium (Ca), inorganic phosphates (Pi), pyridinoline (Pyd) and 17 beta-estradiol (E2) concentration and the bone alkaline phosphatase (BAP) activity were investigated. The samples were taken from 11 mares on 60 +/- 10 and 20 +/- 10 days before foaling, and 20 +/- 10 and 60 +/- 10 days after foaling. The concentration/activity of Ca, Pi, Pyd and RG-7112 cost BAP increased significantly in early lactation, but the Pyd than decreased in the 4th period. A significant correlation was observed between the E2 and bone metabolism parameters. The results indicate low maintenance of normocalcaemia with reduced bone synthesis in late pregnancy and prove the role of estradiol in bone metabolism in mares during pregnancy and lactation. (C) 2009 Elsevier Ltd. All rights reserved.”
“Background: Endothelial progenitor cells (EPCs) are known to play a significant role in reendothelialization and vascular repair. Recently, a mineralocorticoid receptor was demonstrated to be expressed by EPCs. The study aimed to evaluate a potential influence of eplerenone treatment on the total number of EPCs in patients with chronic heart failure.