48 and 471.17 mg/kg body weight respectively. The extract at 500 and 1000 mg extract\kg body weight doses produced significant (P < 0.05) decrease in fluid and feed intake, as well as body weight. The haematological parameters were normal except a significant (P < 0.05) increase

check details in platelet counts observed at all dose levels used. At 1000 mg extract/kg body weight dose, the extract exerted a significant (P < 0.05) decrease that lies within the normal range values of serum aspartate, alanine transaminase and creatinine levels for this animal species. Histological findings indicated possible toxicity in the Liver, Lungs, Kidney, Testes and Uterus At 1000 mg/kg. These results suggest that oral administration of C. Febrifuga may not produce severe toxic effects at doses lower than 500mg extract/kg body weight.”
“The interactions between wine yeasts and wine lactic acid bacteria were evaluated The double-layer

plate-growth method showed bacterial inhibition by yeasts as the most common interaction being Oenococcus oeni more sensitive than Lactobacillus hilgardu During sequential inoculations in the media fermented by Saccharomyces cerevisiae mc2 or Candida pulchemma 3 showed strongest inhibition by S cerevisiae The inhibitory effect exerted by S cerevistae mc2 on O oeni X(2)L and L hilgardu 5w growth could be due to a synergistic effect between fermentation metabolites and another compound(s) with a molecular size of 3-10 kDa The last compound (s) was partially sensitive to Pitavastatin protease and heat treatments suggesting a peptidic nature structure Although this yeast inhibited O oeni growth did not affect the malolactic activity The peptic: inhibitory compound(s) heat and protease sensitive showed a molecular weight between 3 and 10 kDa Flow cytometry revealed different physiological responses of O oeni and L hilgardu to peptidic fraction C pulchemma would exert Its inhibitory effect on bacteria through low molecular weight metabolites (C) 2010 Elsevier Ltd All rights reserved”
“The objective of this study was to evaluation antiviral activities

of the extracts from the seed, fruit skin and aerial parts of ten registered varieties Cicer arietinum (Chickpea) against Herpes simplex type 1 (HSV-1) and Parainfluenza-3 (PI-3) viruses. Madin-Darby selleck chemicals llc Bovine Kidney and Vero cell lines were employed for antiviral assessment of the Cicer arientinum L. extracts, in which acyclovir for HSV-1 and oseltamivir for PI-3 were tested as reference drugs. This is the first report showing that C. arietinum seed extracts of Cse-5 possesses significant antiviral activity both of DNA (32 – 4 mu g ml(-1)) and RNA (32 16 mu g ml(-1)) viruses compared to the fruit skin and aerial part extracts as well as the controls. Besides, the extracts of fruit skin (Cfs-4) and aerial parts (Cap-5) showed remarkable activity against DNA viruses at 32 – 1 mu g ml-(1).