32 and 0.45, respectively (p < 0.001). The adjusted genetic correlation between eGFR and CIMT was from -0.20 to -0.28 (p < 0.05), whereas

there was no genetic correlation between ACR and CIMT. Conclusion: Kidney selleck kinase inhibitor function is a surrogate marker of carotid atherosclerosis and further studies of the pleiotropic relationships between CIMT and eGFR are warranted. Copyright (C) 2012 S. Karger AG, Basel”
“Highly proliferative cells, including cancer cells, require a constant supply of molecular building blocks to support their growth. To acquire substrates such as glucose and amino acids from the extracellular space, dividing cells rely on transporter proteins in the plasma membrane. Numerous studies link transcriptional and post-translational control of nutrient transporter expression with proliferation, highlighting the importance of nutrient transporters in both physiologic and pathologic growth. Here we review recent work that spotlights the crucial role of nutrient transporters in cell growth and proliferation,

discuss post-translational mechanisms for coordinating expression of different transporters, and consider the therapeutic potential of targeting these proteins in cancer and other diseases characterized by inappropriate cell division.”
“NeuroAid (MLC601 and MLC901), a Traditional Medicine used in China for patients learn more after stroke has been reported in preclinical models of ischemia to induce neuroprotection and neuroplasticity.

This work shows the effects of MLC901 on an in vitro model of oxygen glucose deprivation (OGD). MLC901 prevents neuronal death induced by 120 min OGD and decreases the exaggerated Ca2+ entry in mature cortical neurons exposed to 120 min OGD. The neuroprotective effect of MLC901 is associated with a large hyperpolarization of similar to 20 mV which is antagonized by glibenclamide, the specific inhibitor of K-ATP channels. In addition MLC901 strengthens the activation of K-ATP channels. MLC901 has been directly shown to act as an activator AZD7762 concentration of K-ATP channels as potent as the classical K-ATP channel opener. The capacity of MLC901 to produce a large hyperpolarization, particularly in neurons that have suffered from energy deprivation probably plays an important role in the neuroprotective effects of this traditional medicine that comes in addition to its previously demonstrated neuroregenerative properties. (C) 2012 Elsevier Ltd. All rights reserved.”
“In recent years proteomics became increasingly important to functional genomics. Although a large amount of data is generated by high throughput large-scale techniques, a connection of these mostly heterogeneous data from different analytical platforms and of different experiments is limited. Data mining procedures and algorithms are often insufficient to extract meaningful results from large datasets and therefore limit the exploitation of the generated biological information.