01). IFN production after 12 weeks of IFN therapy was significantly increased only in responders, and faithfully predicted the response. Unlike untreated aviremic patients, patients who became aviremic as a result of IFN therapy showed low IFN production by pDCs. Conclusion: The IFN-producing capacity of pDCs is closely associated with viral loads and response to IFN therapy in both adult and pediatric HCV patients. Therefore, the stimulation of endogenous IFN production by pDCs may contribute to the therapeutic efficiacy of IFN in HCV infection, and can be used as a novel method

of its prediction. The role of plasmacytoid dendritic cells in HCV pathogenesis and response IFN therapy in children, adults Key Word(s): 1. pDCs; 2. pathogenesis of HCV ; 3. IFN therapy; 4. viral loads ; Presenting

Author: GUIJIE XIN Additional Authors: LISHA SONG, XIUJUAN SHA, WEIMIN YANG Corresponding Author: GUIJIE XIN Affiliations: 1st hospital of ALK inhibitor Jilin University Objective: In recent years,most patients R788 with acute viral hepatitis E are sporadic cases, and limited epidemics have occurred in few countries.HEV is one of the main pathogens causing sporadic cases of acute hepatitis in adult in China.With high rate of HBV infection, our country has a mass of patients of chronic viral hepatitis B (CHB) or HBV-induced liver cirrhosis(HLC). So, there is a high incidence of HEV co-infection in HBV patients. The idea that HEV co-infection in patients of chronic liver can accentuate further disease had been put forward by some scholars, as well as the exist of interaction between HEV and HBV. However, no final conclusions have yet been reached on these matters.The high incidence and severe impact on prognosis of overlapping infection of HBV

and HEV cause our reflection.In this research, patients in Jilin province were investigated selleck kinase inhibitor to realize the clinical manifestations and current situation of HEV co-infection in chronic viral hepatitis B,and provide more evidences for the impaction of HEV. Methods: Retrospective analysis of 188 sporadic cases of acute hepatitis E was made,which were collected from 1st hospital of Jilin University from January 2005 to October 2011. Comparative analysis of clinical data was made between the 165 patients of HEV infection alone and 13 patients of HEV co-infection in CHB,which all came from the 188 sporadic cases of acute hepatitis E. Serological studies of anti-HEV IgM and anti-HEV IgG was made in patients with HLC,who were in hospital from December 2011 to June 2012 in 1st hospital of Jilin University. The clinical characteristics and laboratory reports of HEV co-infection of CHB and HLC were analysed. Clinical data of 165 patients of HEV infection alone and 13 patients of HEV co-infection in CHB were compared with 24 patients of HLC with positive anti-HEV IgM, which consisted of 6 sporadic cases of acute hepatitis E and 18 cases of HLC with positive anti-HEV IgM detected in this experiment test.