However, the recent observation of two patients, JR and AP, with dissociated performance in pointing to body parts leads to question this model. JR presented a deficit in pointing to his own body parts, while his capacity to point to the body parts of other persons was not altered. AZD6244 AP exhibited the reverse pattern of impairment. Lesion study indicated a putative area of dysfunction setting in the left superior parietal lobule (SPL) in JR, and in the left inferior parietal. lobule (IPL) in AP. This double dissociation, along with two subsequent

neuroimaging studies, suggests that the left SPL and IPL participate in the building of differential representations between oneself and other individuals. (C) 2008 Elsevier Masson SAS. All rights reserved.”
“Measles is one of the most contagious human infectious diseases and remains a major cause of childhood morbidity and mortality worldwide. The signaling lymphocyte activation molecule (SLAM), also called CD150, is a cellular receptor for measles virus (MV), presumably accounting for its

tropism for immune cells and its immunosuppressive properties. On the other hand, pathological studies have shown that MV also infects epithelial cells at a later stage of infection, although its mechanism has so far been unknown. In this study, we show that wild-type MV can infect and produce syncytia in human polarized epithelial cell lines independently of SLAM and CD46 (a receptor for the vaccine strains of MV). Progeny A-769662 order viral particles are released exclusively from the apical surface of these polarized epithelial cell lines. We have also identified amino acid residues on the W attachment protein that are likely to interact with a putative receptor on epithelial cells. All of these residues have aromatic side chains and may form a receptor-binding Liothyronine Sodium pocket located in a different position from the putative SLAM- and CD46-binding sites on the MV attachment protein. Thus, our results indicate that MV has an intrinsic ability to infect both polarized

epithelial and immune cells by using distinctive receptor-binding sites on the attachment protein corresponding to each of their respective receptors. The ability of W to infect polarized epithelial cells and its exclusive release from the apical surface may facilitate its efficient transmission via aerosol droplets, resulting in its highly contagious nature.”
“We review the findings of 24 fMRI studies examining activations in the premotor cortex (Brodmann’s areas 6 and 44) during passive observation of actions. We found that such activations regularly occurred. Looking for functional differentiation in the premotor cortex, we found that one parameter was associated with systematic differences in location: this was the presence or absence of targets.