More detail in Table 1 and Figure 2. Table 1 Distribution of expression of hOGG1, VDAC1, HK-2 in VX-765 datasheet control and case groups n hOGG1 VDAC1 HK-2     – + +% – + +% – + +% Control 20 17 3 15.0 5 15 75.0 12 8 40.0 Case 45 10 35 77.8 5 40 88.9 10 35 77.8 total 65 27 38 58.5 10 55 84.6 22 43 66.2 χ 2   22.47 1.12 8.83 P   0.000 0.289 0.003 Note: P value of χ 2 is indicative of result of Selleck BLZ945 comparison between control and Cases, When P value is below standard of 0.05, the level of difference

is significant. Figure 2 Distribution of expression of hOGG1, VDAC1, HK-2 in control and case. Further, we analyzed the divided Cases samples according to pathology diagnosis for more valuable information. As

described in the Table 2, Figure 3, the proportion of positive expression of hOGG1 and HK-2 showed an increasing trend from Control, MCC, ICC to SCC in order. To VDAC1, the increasing trend of positive proportion was not observed. Table 2 Expression of hOGG1, VDAC1, HK-2 in BB-94 molecular weight classified cervical biopsy samples   hOGG1 VDAC1 HK-2   – + +% – + +% – + +% Control 17 3 15.0 5 15 75.0 12 8 40.0 MCC 6 9 60.0 1 14 93.3 4 11 73.3 ICC 3 14 82.4 3 14 82.4 2 15 88.2 SCC 1 12 92.3 1 12 92.3 4 9 69.2 Linear χ 2 23.295 1.171 5.207 P 0.000 0.279 0.023 Note: MCC, ICC and SCC were explained in abbreviations, Linear χ 2 was used to analyze trend of expression from control, MCC, ICC to SCC in order. When P < 0.05, the trend is significant. Figure 3 Expression of hOGG1, VDAC1, HK-2 in classified cervical biopsy samples. Comparison of consistency level of hOGG1, VDAC1 and HK-2 In order to observe the consistency of expression hOGG1, VDAC1 and HK-2, Pair χ 2 test and Kappa value was used to analyze the consistency level of three pairs of hOGG1--VDAC1, hOGG1--HK-2, VDAC--HK-2. As showed in the Table 3, Overall, there was a low level of consistency expression in pairs of hOGG1--VDAC1, VDAC--HK-2 and hOGG1--HK-2. Table 3 The consistency level of expression of hOGG1, VDAC1, HK-2 in cervical samples     VDAC1 HK-2     HK-2     - + - +     - + hOGG1 - 5 22 14 Cyclic nucleotide phosphodiesterase 13

VDAC1 – 5 4   + 5 33 8 30   + 17 39 χ 2 9.48 0.76   6.86 P 0.002 0.383   0.007 Kappa 0.059 0.316   0.157 Note: Pair χ 2 or McNemarχ 2 is used to analyze consistency level commonly, When P < 0.05, the consistency level is not significant. Similarly, When Kappa < 0.45, indicating a low consistency level. Relationship between expression degree of hOGG1, VDAC1, HK-2 and classified cervical biopsy samples 65 cervical biopsy samples were classified as -, ±, + and ++ four types or Control, MCC, ICC and SCC four groups according to proportion of positive cell or pathology diagnosis. As a result, we observed that relationship between expression of hOGG1, VDAC1, HK-2 and graded pathology types of cervical biopsy tissue.