In refractory GERD patients, the treatment of weakly acid and weakly alkaline reflux is more effective to PPI treatment. Key Word(s): 1. GERD; 2. PPI; Presenting Author: RAJESHKUMAR PARAMASIVAM Additional Authors: SHASHIKUMAR MENON, SARAVANAN ARJUNAN, OOI TIAM, NORHANIZA BAKAR, MAYLENE WONG, CHAN KAI Corresponding Author: RAJESHKUMAR PARAMASIVAM Affiliations: UiTM Objective: To determine presence of celiac disease (CD) among high risk patients in Kuala Lumpur General Hospital from December 2011 to March

2012. Methods: Patients from 12–70 years of age, presenting with unexplained iron deficiency anemia (IDA), chronic diarrhea or weight loss were recruited. A gastroscopy with total of 6 biopsies from 2nd part of duodenum was performed. Patients with other causes for IDA, chronic diarrhea and weight loss were excluded. All of them had anti-transglutaminase antibody (anti-tTG) and anti-gliadin IDO inhibitor antibody (AGA) tested using immunoblot test. Patients with positive anti-tTG, with or without

duodenal histopathological changes were diagnosed as classical or atypical CD respectively. Results: Total of 29 patients were recruited for this study. 13 were excluded. 16 patients were analyzed, 11 had IDA and 5 presented with unexplained chronic diarrhea with weight loss. The mean (SD) hemoglobin was 8.4 (1.5) g/dl among the IDA patients. Indians were the largest group (n = 7). 2 (12.5%) patients had positive anti-tTG comprising of 1 Malay and 1 Indian. Duodenal histology showed chronic duodenitis and the other was normal; sufficient KU-60019 in vivo to be diagnosed as atypical CD. Total of 5 patients had positive AGA antibody. Neither transferrin saturation (P value = 0.122) nor race (P value = 0.95) showed statistical difference. Conclusion: Celiac disease is not uncommon among high risk population in Malaysia. Larger scale studies are required to determine the prevalence of CD among high risk population. Duodenal

biopsy and celiac serology 上海皓元医药股份有限公司 must be done routinely in high risk patients. Key Word(s): 1. Celiac disease; 2. Presence; 3. Malaysia; 4. High risk; Presenting Author: HAEWON KIM Additional Authors: JIE-HYUN KIM Corresponding Author: HAEWON KIM Affiliations: Gangnam Severance Hospital Objective: Locally advanced esophageal cancer is highly aggressive and fatal, because they often persist or recur after definitive concurrent chemoradiation (CCRT). But, little is known about the failure patterns after definitive CCRT, especially in esophageal squamous cell carcinoma (SCC). Thus, we evaluated treatment failure patterns after definite CCRT and predictive factors of treatment response in esophageal SCC. Methods: We retrospectively evaluated 136 patients with esophageal SCC treated with definitive CCRT at Severance and Gangnam Severance Hospital from January 2005 to December 2010. We analyzed the factors which affected the complete remission after CCRT.