, 2009 and Mahncke et al., 2006a). Intuitively, an obvious target might be the ability to form and retrieve representations of episodes, which is

thought to depend on the medial temporal lobes (MTL) (Eichenbaum et al., 2007). However, it is generally believed GW786034 datasheet that memory formation and retrieval constantly engage the MTL, even when one is not attempting to do so. Thus, it is not clear whether repeated performance of episodic encoding and retrieval tasks would further tax MTL function and result in general improvements in memory. Instead, research has largely focused on processes that contribute to effective memory encoding and retrieval. For instance, one view is that memory impairments in aging and in many clinical disorders reflect a “downstream” consequence of primary sensory deficits. According to this view, the fidelity of sensory inputs degrades with age and may be affected by various neurological and psychiatric conditions. Peripheral sensory

deficits, in turn, could lead to degraded encoding of events and possibly impaired episodic memory performance (Mahncke et al., 2006a). Thus, if perceptual abilities can be improved through training tasks (e.g., phoneme discrimination with degraded stimuli), this could lead to improved memory encoding. Working from this premise, some companies have designed products aimed at improving perceptual abilities through Nintedanib cost cognitive training. For example, Posit Science (http://www.positscience.com/) has developed an intervention program using computerized tasks that place increasing demands on perceptual processing (as well as other modules which emphasize more high-level processing). This program is based in part on findings that, even in the adult brain, there to is substantial plasticity in primary sensory regions (Mahncke et al., 2006a). A strength of perceptual training approaches is that they target a potential cause of memory problems in the real world whose impact

may be underestimated in laboratory experiments. In laboratory or clinical settings, researchers typically try to ensure that stimuli to be learned are highly discriminable, but in the real world, the stimuli that we encounter are often embedded in noisy contexts (such as words spoken in a loud room, or a face that is seen under poor lighting conditions). That said, it is important to point out that perceptual degradation might not be a primary cause of memory impairments seen over the course of normal aging or in memory disorders (Murphy et al., 2000). Another approach to ability training is based on evidence showing that the prefrontal cortex (PFC) plays a critical role in successful episodic memory encoding and retrieval (see Ranganath and Blumenfeld, 2008, for review). Recent work has demonstrated that prefrontal functioning can be improved through behavioral training.