Here, we report that IDR E804 inhibited endothelial cell proliferation, migration and tube formation in vitro assays using human umbilical vein endothelial cells Also, IDR E804 inhibited tumor development through a reduction in CD31 and Ki 67 constructive cells and enhanced apoptosis inside the allograft colon tumor model. Moreover, mechanistically, IDR E804 straight selleck inhibitor inhibitor aurora inhibitors inhibits VEGFR two kinase action in vitro and causes a re duction of phosphorylation of VEGFR two, AKT and ERK in VEGF stimulated HUVECs. Our research recommend that IDR E804 can be a novel angiogenesis inhibitor and can be a prospective drug candidate for angiogenesis related conditions.