Relative risk of occupational disability within the first 3 years

Relative risk of occupational disability within the first 3 years of follow-up was even more strongly associated with γ-GT than within the entire follow-up period. After exclusion of the first 3 years of follow-up, the results did not materially change compared to the analysis without left truncation. Again, risk of occupational disability was significantly increased at all γ-GT levels compared to the lowest group. The monotonically increasing

association of γ-GT with disability pension could also be observed in dose-response analyses using γ-GT as a continuous variable (Fig. 1). The increase in hazard ratios was steeper at lower AZD1208 γ-GT concentrations than at higher levels. Additional analyses with stratification by the presence or absence of cardiovascular http://www.selleckchem.com/products/bmn-673.html diseases, diabetes mellitus, and diseases of the liver, bile, and pancreas, which all might cause elevations of γ-GT levels, did not indicate any relevant confounding or interaction by these conditions (data not shown). Information on cause of disability could be obtained for 2,713

out of 2,998 (90.5%) cases of disability pension. With 1,244 (45.9%) cases, musculoskeletal disorders represented the most common cause of disability pension, with half of them being due to dorsopathies. The second most common cause was cardiovascular diseases (17.3%), followed by mental disorders (8.9%), and cancer (8.0%). Frequencies and hazard ratios (multiple adjusted) of cause-specific disability pension are shown in Table 3. Risk of disability monotonically increased with γ-GT activity for cardiovascular diseases, respiratory diseases, as well as musculoskeletal disorders, with significant increased risks for the two highest γ-GT categories. For the latter, the relative MCE risk was even significantly elevated at all γ-GT categories compared with the reference group. This pattern did not change

when separately considering disability pension due to dorsopathy as well as due to osteoarthritis, the two most predominant musculoskeletal causes of disability in our cohort (data not shown). Increased risks of occupational disability due to all of the assessed causes were observed in the highest quartile of γ-GT concentration. With an age-adjusted hazard ratio of 9.86 (95% confidence limits: 3.10; 30.21), the strongest risk elevation was observed for occupational disability due to diseases of the digestive system, which were predominantly diseases of the liver, bile, and pancreas. The significant increase of occupational disability due to other causes among men with γ-GT concentrations in the highest quartile was mainly due to diabetes. Serum γ-GT is not merely a sensitive marker for liver and bile disorders, but also a risk marker for a multiplicity of other chronic diseases.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>